The only acknowledged exception to date is IL-35, which can sign by way of a gp130 homodimer, but only induces phosphorylation of STAT1, not STAT3. In distinction, IL-six, IL-eleven or Hyper-IL-6, which also recruit a gp130 homodimer, induce phosphorylation of equally STAT1 and STAT3
It was earlier shown that mutation of C92 to serine in p35 did not prevent IL-12 formation and perform, suggesting that the disulfide bond among p40 and p35 mediates security,…