Recombinant Human Eotaxin-2 (CCL24)
Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation). Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues. GDC-0813
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50.0-100.0 ng/ml.
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AA Sequence
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VVIPSPCCM FFVSKRIPE NRVVSYQLS SRSTCLKGG VIFTTKKGQ QFCGDPKQE WVQRYMKNL DAKQKKASP RARAVA
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| Research Interest: | , Proliferation and Cell Cycle, |
| Cell Type: | , , , |
| Protein Cross Reactivity: | NULL |