Recombinant Human Eotaxin (CCL11)
Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions. Recombinant human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. R431
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse, Human + Hamster, Human + Guinea Pig
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Biological Activity
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Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.
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AA Sequence
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GPASVPTTC CFNLANRKI PLQRLESYR RITSGKCPQ KAVIFKTKL AKDICADPK KKWVQDSMK YLDQKSPTP KP
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| Research Interest: | , |
| Cell Type: | , , Endothelial Cells |
| Protein Cross Reactivity: | Mouse, Human + Hamster, Human + Guinea Pig |