Animal-Free Recombinant Human M-CSF
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant human M-CSF is a 36.8 kDa homodimeric protein containing two 159 amino acid polypeptide subunits. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Monkey, Mouse, Rat
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Biological Activity
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The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NSF-60 cells ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
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AA Sequence
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MEEVSEYCS HMIGSGHLQ SLQRLIDSQ METSCQITF EFVDQEQLK DPVCYLKKA FLLVQDIME DTMRFRDNT PNAIAIVQL QELSLRLKS CFTKDYEEH DKACVRTFY ETPLQLLEK VKNVFNETK NLLDKDWNI FSKNCNNSF AECSSQGHE RQSEGS
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| Research Interest: | , , , Proliferation and Cell Cycle |
| Cell Type: | , |
| Protein Cross Reactivity: | Monkey, Mouse, Rat |