Animal-Free Recombinant Human G-CSF
G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Monkey,Mouse, Pig
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Biological Activity
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The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
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AA Sequence
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TPLGPASSL PQSFLLKCL EQVRKIQGD GAALQEKLC ATYKLCHPE ELVLLGHSL GIPWAPLSS CPSQALQLA GCLSQLHSG LFLYQGLLQ ALEGISPEL GPTLDTLQL DVADFATTI WQQMEELGM APALQPTQG AMPAFASAF QRRAGGVLV ASHLQSFLE VSYRVLRHL AQP
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| Research Interest: | , , , , Inflammation, |
| Cell Type: | , , Endothelial Cells |
| Protein Cross Reactivity: | Monkey,Mouse, Pig |