Animal-Free Recombinant Human IL-16 (121 a.a.)
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Determined by its ability ot chemoattract human CD4+ T-Lymphocytes using a concentration range of 50.0-100.0 ng/ml.
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AA Sequence
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SAASASAAS DVSVESTAE ATVCTVTLE KMSAGLGFS LEGGKGSLH GDKPLTINR IFKGAASEQ SETVQPGDE ILQLGGTAM QGLTRFEAW NIIKALPDG PVTIVIRRK SLQSKETTA AGDS
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| Research Interest: | , |
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| Protein Cross Reactivity: | NULL |