Recombinant Human sTRAIL Receptor-2
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which can activate the cells apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain. XMD8-94
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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sTRAIL Rec 2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of sTRAIL Rec 2, TRAI
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AA Sequence
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MESALITQQ DLAPQQRVA PQQKRSSPS EGLCPPGHH ISEDGRDCI SCKYGQDYS THWNDLLFC LRCTRCDSG EVELSPCTT TRNTVCQCE EGTFREEDS PEMCRKCRT GCPRGMVKV GDCTPWSDI ECVHKES
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| Research Interest: | , |
| Protein Cross Reactivity: | NULL |