Anti-Mouse/Rat CD29 SAFIRE Purified
The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion. NVP-TNKS658
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Clone
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HMb1-1
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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| Research Interest: | |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Ridger, V. C., Wagner, B. E., Wallace, W. A., & Hellewell, P. G. (2001). Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. The Journal of Immunology,166(5), 3484-3490. Noto, K., Kato, K., Okumura, K., & Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb. International immunology, 7(5), 835-842. Sangaletti, S., Di Carlo, E., Gariboldi, S., Miotti, S., Cappetti, B., Parenza, M., … & Colombo, M. P. (2008). Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer research, 68(21), 9050-9059. |