Anti-Mouse CD150 (SLAM) FITC
The 9D1 monoclonal antibody specifically binds to mouse CD150, a 75-95 kD single chain type I transmembrane glycoprotein also known as signaling lymphocyte activation molecule (SLAM). It is expressed on B cells, dendritic cells, T cells, and thymocytes. Upon activation, its expression is upregulated. SLAM signaling in Th1 cells is reported to induce IFN-γ production. The 9D1 antibody is reported to activate the CD150 receptor. GSK-J6
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Clone
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9D1
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Format: |
FITC
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Rat IgG1
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Howie, D., Okamoto, S., Rietdijk, S., Clarke, K., Wang, N., Gullo, C., … & Kuchroo, V. (2002). The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production. Blood, 100(8), 2899-2907. Chi, A. W., Chavez, A., Xu, L., Weber, B. N., Shestova, O., Schaffer, A., … & Bhandoola, A. (2011). Identification of Flt3+ CD150− myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood, 118(10), 2723-2732. Wang, N., Satoskar, A., Faubion, W., Howie, D., Okamoto, S., Feske, S., … & Terhorst, C. (2004). The cell surface receptor SLAM controls T cell and macrophage functions. The Journal of experimental medicine, 199(9), 1255-1264. |