Anti-Rat CD86 (B7-2) FITC
The 24F monoclonal antibody specifically reacts with CD86 (B7-2), a 90 kDA surface receptor present on antigen presenting cells and activated B and T cells. CD86 is a ligand for CD28 and CD152 and plays an essential role in B cell-T cell costimulatory interactions.
The 24F antibody is capable of blocking the co-stimulatory activity of CD86.
|
Clone
|
24F
|
|
Format: |
FITC
|
|
Applications
|
FC
|
|
Reactivity
|
Rat
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: | |
| Cell Type: | |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Maeda, K., Sato, T., Azuma, M., Yagita, H., & Okumura, K. (1997). Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology, 9(7), 993-1000. Damoiseaux, J. G., Yagita, H., Okumura, K., & van Breda Vriesman, P. J. (1998). Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. Journal of leukocyte biology, 64(6), 803-809. BLUESTONE, J. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity, 2, 555-559. |