Anti-Human CD85j (ILT2) SAFIRE Purified
The HP-F1 monoclonal antibody reacts with human CD85j, a 110 kDA single transmembrane glycoprotein. The CD85 molecules encompass a large immunoregulatory family called Leuokocyte Immunoglobulin-like Receptors (LIRs) and Ig-Like Transcripts (ILTs). CD85j is also knows as Ig-like transcpript (ILT2) and leukocyte Ig-like receptor (LIR-1). It is expressed on subsets of NK, B and T cells and on myeloid cells such as monocytes and dendritic cells. CD85j is involved in viral infections. AF38471
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Clone
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HP-F1
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | , |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Colonna, M., Navarro, F., Bellón, T., Llano, M., García, P., Samaridis, J., … & López-Botet, M. (1997). A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. The Journal of experimental medicine, 186(11), 1809-1818. Bellón, T., Kitzig, F., Sayós, J., & López-Botet, M. (2002). Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. The Journal of Immunology, 168(7), 3351-3359. Tenca, C., Merlo, A., Merck, E., Bates, E. E., Saverino, D., Simone, R., … & Ciccone, E. (2005). CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells. The Journal of Immunology, 174(11), 6757-6763. |