Anti-Human/Mouse Notch1 PE
The mN1A monoclonal antibody reacts with the intracellular domain of human and mouse Notch1 with high affinity for the activated intracellular form and lower affinity for the full length heterodimeric Notch1 forms. It does not react with Notch2,3, or 4 and does not cross-react with rat thymocytes. The neurogenic locus homolog protein 1 (Notch1) is a trasmembrane receptor that regulates cell fate decisions. It is expressed in CD4-CD8- and CD4-CD8+ thymocytes, and plays a role in the regulation of myelopoiesis and lymphopoiesis. VcMMAE
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Clone
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mN1A
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Format: |
PE
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Applications
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FC
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Reactivity
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Human, Mouse
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | , , Proliferation and Cell Cycle |
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Huppert, S. S., Le, A., Schroeter, E. H., Mumm, J. S., Saxena, M. T., Milner, L. A., & Kopan, R. (2000). Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature, 405(6789), 966-970. Milner, L. A., & Bigas, A. (1999). Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation. Blood, 93(8), 2431-2448. Varnum-Finney, B., Purton, L. E., Yu, M., Brashem-Stein, C., Flowers, D., Staats, S., … & Bernstein, I. D. (1998). The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood, 91(11), 4084-4091. |