Anti-Human CD338 (ABCG2) PE
The 5D3 monoclonal antibody binds to CD338 (ABCG2), a multi-drug resistance (MDR) protein that is highly expressed on primitive side population stem cells, a subset of cells that express low or undetectable levels of CD34. CD338 is involved in the transport of molecules across extra- and intra-cellular membranes. TAK-244
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Clone
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5D3
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG2b, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Özvegy-Laczka, C., Laczkó, R., Hegedűs, C., Litman, T., Várady, G., Goda, K., … & Sarkadi, B. (2008). Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. Journal of Biological Chemistry,283(38), 26059-26070. Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A. M., Sampath, J., Morris, J. J., … & Sorrentino, B. P. (2001). The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature medicine, 7(9), 1028-1034. Bunting, K. D. (2002). ABC transporters as phenotypic markers and functional regulators of stem cells. Stem cells, 20(1), 11-20. |