Anti-Mouse CD11a SAFIRE Purified
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1). LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions. LDE226 (Diphosphate)
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Clone
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M17/4
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Mouse
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Isotype:
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Rat IgG2a, kappa
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| Research Interest: | |
| Cell Type: | , Th1 cells |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Saban, M. R., Saban, R., Bjorling, D., & Haak-Frendscho, M. (1997). Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration. Journal of leukocyte biology,61(4), 445-451. Zhao, Y., & Iwata, M. (1995). Cross-linking of the TCR–CD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506. International immunology, 7(9), 1387-1396. Kootstra, C. J., Van Der Giezen, D. M., Van Krieken, J. H. J. M., De Heer, E., & Bruijn, J. A. (1997). Effective treatment of experimental lupus nephritis by combined administration of anti‐CD11a and anti‐CD54 antibodies. Clinical & Experimental Immunology, 108(2), 324-332. |