Anti-Human TIM3 SAFIRE Purified
The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection. THZ2
|
Clone
|
F38-2E2
|
|
Format: |
SAFIRE Purified
|
|
Applications
|
FA
|
|
Reactivity
|
Human
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: | |
| Cell Type: | , , , Th17 cells |
|
Preperation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., … & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells. Blood, 113(9), 1957-1966. Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., … & Kuchroo, V. K. (2009). TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European journal of immunology, 39(9), 2492-2501. Koguchi, K., Anderson, D. E., Yang, L., OConnor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of experimental medicine, 203(6), 1413-1418. |