Anti-Human CD184 (CXCR4) Purified
The 12G5 monoclonal antibody specifically bind to human CD184 (CXCR4), a seven-transmembrane G-protein-coupled receptor. It is widely expressed on endothelial cells, hematopietic cells, and also on naïve T cell subsets. CD184 is the receptor for SDF-1 and an alternative receptor for HIV-1. The 12G5 antibody is reported to inhibit SDF-1 induced chemotaxis and calcium influx and some CD4-dependent infections of HIV-1. Avibactam (sodium)
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Clone
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12G5
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Format: |
Purified
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG2a, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., & Mackay, C. R. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proceedings of the National Academy of Sciences,94(5), 1925-1930. Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science, 272(5263), 872-877. Simmons, G., Wilkinson, D., Reeves, J. D., Dittmar, M. T., Beddows, S., Weber, J., … & Clapham, P. R. (1996). Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. Journal of Virology, 70(12), 8355-8360. |