Anti-Human CD3 PE
The Hit3a monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.
Ivosidenib
|
Clone
|
Hit3a
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
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Mouse IgG2a, kappa
|
| Research Interest: |
|
| Cell Type: |
, , , Th17 cells |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Lanier, L. L., Allison, J. P., & Phillips, J. H. (1986). Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. The Journal of Immunology, 137(8), 2501-2507.
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MED: 19049862
Anti-Human CD3 PE
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.
GSK-J5
|
Clone
|
OKT3
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
MouseIgG2a, kappa
|
| Research Interest: |
|
| Cell Type: |
, , Th17 cells, |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., … & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.
|
MED: 19049897
Anti-Human CD3 PE
The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
SAR406
|
Clone
|
UCHT1
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: |
|
| Cell Type: |
, , , Th17 cells |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Beverley, P. C., & Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. European journal of immunology, 11(4), 329-334.
|
MED: 19049901
Anti-Human CD3 PE
The Hit3a monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.
Ivosidenib
|
Clone
|
Hit3a
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
Mouse IgG2a, kappa
|
| Research Interest: |
|
| Cell Type: |
, , , Th17 cells |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Lanier, L. L., Allison, J. P., & Phillips, J. H. (1986). Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. The Journal of Immunology, 137(8), 2501-2507.
|
MED: 19049862
Anti-Human CD3 PE
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.
GSK-J5
|
Clone
|
OKT3
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
MouseIgG2a, kappa
|
| Research Interest: |
|
| Cell Type: |
, , Th17 cells, |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., … & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.
|
MED: 19049897
Anti-Human CD3 PE
The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
SAR406
|
Clone
|
UCHT1
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: |
|
| Cell Type: |
, , , Th17 cells |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
McMichael, A. J. (1987). Leucocyte typing III. Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
Beverley, P. C., & Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody. European journal of immunology, 11(4), 329-334.
|
MED: 19049901