Anti-Human CD284 (TLR4) SAFIRE Purified
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4. SCH 546739
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Clone
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HTA125
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG2a, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Akashi, S., Ogata, H., Kirikae, F., Kirikae, T., Kawasaki, K., Nishijima, M., … & Miyake, K. (2000). Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2. Biochemical and biophysical research communications, 268(1), 172-177. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., & Kimoto, M. (1999). MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. The Journal of experimental medicine,189(11), 1777-1782. Mirlashari, M. R., & Lyberg, T. (2003). Expression and involvement of Toll-like receptors (TLR) 2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis. Medical science monitor: international medical journal of experimental and clinical research, 9(8), BR316-24. |