Anti-Human CD16 FITC


The CB16 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils. ALS-8113

Clone
CB16
Format:
FITC
Applications
FC
Reactivity
Human
Isotype:
Mouse IgG1, kappa
Research Interest:
Cell Type: ,
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:

Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., … & Malavasi, F. (2002). Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. Blood99(7), 2490-2498.

Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., & Coligan, J. E. (2013). Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells. The Journal of Immunology191(4), 1883-1894.

Wirthmueller, U., Kurosaki, T., Murakami, M. S., & Ravetch, J. V. (1992). Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain. The Journal of experimental medicine175(5), 1381-1390.

MED: 19047212

Anti-Human CD16 FITC


The 3G8 monoclonal antibody specifically reacts with human CD16, the low affinity IgG receptor III (FC gamma RIII). CD16 is expressed on granulocytes, monocytes, macrophages, and NK cells and plays a role in NK activation and signal transduction. CD16 is expressed as either CD16a or CD16b. CD16a is a polypeptide-anchored transmembrane protein and CD16b is a glycosylphosphatidylinositol (GPI)-anchored protein that is expressed exclusively on neutrophils. LY2606369

Clone
3G8
Format:
FITC
Applications
FC
Reactivity
Human
Isotype:
Mouse IgG1, kappa
Research Interest:
Cell Type: ,
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:
Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008). Use of an anti‐CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques. Immunology124(2), 215-222.

Perussia, B. I. C. E., & Trinchieri, G. I. O. R. G. I. O. (1984). Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells. The Journal of Immunology132(3), 1410-1415.

Vossebeld, P. J., Homburg, C. H., Roos, D., & Verhoeven, A. J. (1997). The anti-FcγRIII mAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa. The international journal of biochemistry & cell biology,29(3), 465-473.

MED: 19047225

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