Anti-Human CD45 APC-Cyanine7
The HI30 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45. It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.
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Clone
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HI30
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Format: |
APC-Cyanine7
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | |
| Cell Type: | , , , |
| Protein Cross Reactivity: | Chimpanzee |
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., … & Naoe, T. (2006). Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia, 21(1), 136-142. Yoshino, N., AMI, Y., TERAO, K., TASHIRO, F., & HONDA, M. (2000). Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Experimental Animals, 49(2), 97-110. |