Anti-Human CD40 SAFIRE Purified
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation. INCB3344
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Clone
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5C3
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Schlossman, S. F. (1995). Leucocyte typing V: White cell differentiation antigens: Proceedings of the Fifth International Workshop and Conference, Held in Boston, USA 3-7 November, 1993. Oxford University Press. Barclay, A. N., Birkeland, M. L., Brown, M. H., Beyers, A. D., David, S. J., Somoza, C., & Williams, A. F. The Leukocyte Antigen Facts Book. 1993.Academic Prss, London. Challa, A., Pound, J. D., Gordon, J., & Armitage, R. J. (1999). Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells. Allergy, 54(6), 576-583. |