Anti-Human CD30 PE
The Ber-H2 monoclonal antibody specifically reacts with human CD30, a 120kDA type I transmembrane glycoprotein of the tumor necrosis factor receptor superfamily (TNFR) also known as the Ki-1 antigen. CD30 can elicit signals leading to either activation or apoptosis through interaction with CD30 ligand (CD30L). It is expressed by a subset of extrafollicular activated B and T cells, lung macrophages, activated NK cells, lymphomas, and endothelial cells. It is highly expressed on Hodgkins and Reed-Sternberg cells. PNU-159682
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Clone
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Ber-H2
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Schwarting, R., Gerdes, J., Durkop, H., Falini, B., Pileri, S., & Stein, H. (1989). BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol-resistant epitope. Blood, 74(5), 1678-1689. Beljaards, R. C., Meijer, C. J., Scheffer, E., Toonstra, J., Van Vloten, W. A., Van Der Putte, S. C., … & Willemze, R. (1989). Prognostic significance of CD30 (Ki-1/Ber-H2) expression in primary cutaneous large-cell lymphomas of T-cell origin. A clinicopathologic and immunohistochemical study in 20 patients. The American journal of pathology, 135(6), 1169. Horie, R., & Watanabe, T. (1998, December). CD30: expression and function in health and disease. In Seminars in immunology (Vol. 10, No. 6, pp. 457-470). Academic Press. |