Anti-Human CD243 (ABCB1) PE
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp). It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux. Sumanirole (maleate)
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Clone
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UIC2
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG2a
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Mechetner, E. B., & Roninson, I. B. (1992). Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proceedings of the National Academy of Sciences, 89(13), 5824-5828. Chaudhary, P. M., Mechetner, E. B., & Roninson, I. B. (1992). Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]. Blood, 80(11), 2735-2739. Goda, K., Fenyvesi, F., Bacsó, Z., Nagy, H., Márián, T., Megyeri, A., … & Szabó, G. (2007). Complete inhibition of P-glycoprotein by simultaneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. Journal of Pharmacology and Experimental Therapeutics, 320(1), 81-88. |