Product Name :
PCC0208009
Description:
PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .
CAS:
1668565-74-9
Molecular Weight:
497.63
Formula:
C29H35N7O
Chemical Name:
1-4-[bis(2-methylpropyl)amino]-2′-(1H-1,2,3,4-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl-3-(4-methylphenyl)urea
Smiles :
CC1C=CC(=CC=1)NC(=O)NC1=CC(=CC=C1N(CC(C)C)CC(C)C)C1=CC=CC=C1C1NN=NN=1
InChiKey:
CJNMMPAEIYFQIJ-UHFFFAOYSA-N
InChi :
InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .|Product information|CAS Number: 1668565-74-9|Molecular Weight: 497.63|Formula: C29H35N7O|Chemical Name: 1-4-[bis(2-methylpropyl)amino]-2′-(1H-1,2,3,4-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl-3-(4-methylphenyl)urea|Smiles: CC1C=CC(=CC=1)NC(=O)NC1=CC(=CC=C1N(CC(C)C)CC(C)C)C1=CC=CC=C1C1NN=NN=1|InChiKey: CJNMMPAEIYFQIJ-UHFFFAOYSA-N|InChi: InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (200.95 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Abacavir Biological Activity |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Monepantel manufacturer |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PCC0208009 inhibits IDO1 activity in HeLa cells, with an IC50 value of 4.PMID:32152244 52 nM, but it does not change the enzyme activity in vitro, indicating that it acts as an indirect IDO1 inhibitor. PCC0208009 (0-200 nM; 48 hours) dose-dependently suppresses the IDO protein and mRNA expression induced by IFN-γ .|In Vivo:|PCC0208009 (single oral gavage; 50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 60, 120 and 240 min after drug administration in plasma and brain samples, and the highest concentrations of PCC0208009 in plasma and brain are observed at 60 min after administration. Concomitantly, the Kyn/Trp ratio decreases at 60, 120 and 240 min postdose, with the minimum level in the plasma and the brain seen at 60 min post-dose. PCC0208009 (oral gavage; once; 12-50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 30, 60 and 90min after administration to evaluate the antinociceptive effects of PCC0208009 on neuropathic pain.|Products are for research use only. Not for human use.|