Anti-Human CD138 (Syndecan-1) PE
The DL-101 monoclonal antibody specifically reacts with human CD138, a 85-92 kDA type I heparan sulfate proteoglycan. CD138 is known as Syndecan-1 and is expressed on pre-B cells, immature B cells, plasma cells, and malignant plasma cells, to the exclusion of mature circulating B cells. Syndecan-1 is also expressed on vascular smooth muscle, endothelial, neural, and embryonic mesenchymal cells. It is involved in cellular proliferation, cellular migration, and acts as an extracellular matrix receptor. Among the hematopoietic elements, CD138 is a useful marker for plasma cells. GS-9973
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Clone
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DL-101
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Gattei, V., Godeas, C., Degan, M., Rossi, F. M., Aldinucci, D., & Pinto, A. (1999). Characterization of anti‐CD138 monoclonal antibodies as tools for investigating the molecular polymorphism of syndecan‐1 in human lymphoma cells. British journal of haematology, 104(1), 152-162. Fitzgerald, M. L., Wang, Z., Park, P. W., Murphy, G., & Bernfield, M. (2000). Shedding of syndecan-1 and-4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3–sensitive metalloproteinase. The Journal of cell biology, 148(4), 811-824. Itoua Maïga, R., Lemieux, J., Roy, A., Simard, C., & Néron, S. (2014). Flow Cytometry Assessment of In Vitro Generated CD138< b>< sup>. BioMed research international, 2014. |