Product Name :
CBK289001
Description:
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5bMV, TRAP 5bOX and TRAP 5aOX with IC50s of 125 µM, 4.21 µM and 14.2 µM, respectively.
CAS:
1212663-24-5
Molecular Weight:
396.40
Formula:
C19H20N6O4
Chemical Name:
(6S)-6-[3-(2H-1, 3-benzodioxol-5-yl)-1, 2, 4-oxadiazol-5-yl]-N-(propan-2-yl)-1H, 4H, 5H, 6H, 7H-imidazo[4, 5-c]pyridine-5-carboxamide
Smiles :
CC(C)NC(=O)N1CC2N=CNC=2C[C@H]1C1=NC(=NO1)C1=CC2OCOC=2C=C1
InChiKey:
IEYGJIBARBKQMA-AWEZNQCLSA-N
InChi :
InChI=1S/C19H20N6O4/c1-10(2)22-19(26)25-7-13-12(20-8-21-13)6-14(25)18-23-17(24-29-18)11-3-4-15-16(5-11)28-9-27-15/h3-5,8,10,14H,6-7,9H2,1-2H3,(H,20,21)(H,22,26)/t14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Glypican-3/GPC3 Protein, Human (HEK293, Fc) site
Additional information:
CBK289001 is a tartrate-resistant acid phosphatase (TRAP/ACP5) inhibitor. CBK289001 inhibits TRAP 5bMV, TRAP 5bOX and TRAP 5aOX with IC50s of 125 µM, 4.L-Ornithine In Vivo 21 µM and 14.2 µM, respectively.|Product information|CAS Number: 1212663-24-5|Molecular Weight: 396.40|Formula: C19H20N6O4|Chemical Name: (6S)-6-[3-(2H-1, 3-benzodioxol-5-yl)-1, 2, 4-oxadiazol-5-yl]-N-(propan-2-yl)-1H, 4H, 5H, 6H, 7H-imidazo[4, 5-c]pyridine-5-carboxamide|Smiles: CC(C)NC(=O)N1CC2N=CNC=2C[C@H]1C1=NC(=NO1)C1=CC2OCOC=2C=C1|InChiKey: IEYGJIBARBKQMA-AWEZNQCLSA-N|InChi: InChI=1S/C19H20N6O4/c1-10(2)22-19(26)25-7-13-12(20-8-21-13)6-14(25)18-23-17(24-29-18)11-3-4-15-16(5-11)28-9-27-15/h3-5,8,10,14H,6-7,9H2,1-2H3,(H,20,21)(H,22,26)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:31643904 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Only CBK289001 inhibits TRAP3high cell migration in a concentration-dependent manner. Significant inhibition of migration appeared from 24 h after treatment and reduced migration velocity over 30 hours is reached with concentrations of either 20 µM or 100 µM. CBK289001 inhibits TRAP-dependent migration when treating TRAP-overexpressing MDA-MB-231 breast cancer cells.|Products are for research use only. Not for human use.|