Product Name :
AZD4694
Description:
AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).
CAS:
1054629-49-0
Molecular Weight:
258.25
Formula:
C14H11FN2O2
Chemical Name:
2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol
Smiles :
CNC1=CC=C(C(F)=N1)C1=CC2=CC(O)=CC=C2O1
InChiKey:
MYNQXTDIPMCJCR-UHFFFAOYSA-N
InChi :
InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD4694, a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils (Kd = 2.3 nM).|Product information|CAS Number: 1054629-49-0|Molecular Weight: 258.25|Formula: C14H11FN2O2|Chemical Name: 2-[2-fluoro-6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol|Smiles: CNC1=CC=C(C(F)=N1)C1=CC2=CC(O)=CC=C2O1|InChiKey: MYNQXTDIPMCJCR-UHFFFAOYSA-N|InChi: InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tranilast} web|{Tranilast} Prostaglandin Receptor|{Tranilast} NF-κB|{Tranilast} Biological Activity|{Tranilast} Description|{Tranilast} supplier} |Shelf Life: ≥12 months if stored properly.{{Irbesartan} web|{Irbesartan} Apoptosis|{Irbesartan} Technical Information|{Irbesartan} In Vitro|{Irbesartan} custom synthesis|{Irbesartan} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32990167 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue. AZD4694 (4 mL/kg; intravenous injection) inhibits [3H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.|Products are for research use only. Not for human use.|