Product Name :
SMER18
Description:
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington’s disease and familial Parkinson’s disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington’s disease cell and Drosophila melanogaster models, which suggests therapeutic potential.
CAS:
944153-47-3
Molecular Weight:
287.74
Formula:
C16H14ClNO2
Chemical Name:
(2Z)-1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one
Smiles :
C/C(=C/C(=O)C1C=CC(Cl)=CC=1)/NC1C=C(O)C=CC=1
InChiKey:
SNEQASFEVWLKOJ-LUAWRHEFSA-N
InChi :
InChI=1S/C16H14ClNO2/c1-11(18-14-3-2-4-15(19)10-14)9-16(20)12-5-7-13(17)8-6-12/h2-10,18-19H,1H3/b11-9-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Neostigmine methyl} web|{Neostigmine methyl} Cholinesterase (ChE)|{Neostigmine methyl} TGF-beta/Smad|{Neostigmine methyl} Biological Activity|{Neostigmine methyl} Purity|{Neostigmine methyl} custom synthesis}
Shelf Life:
≥12 months if stored properly.{{Ziv-aflibercept} web|{Ziv-aflibercept} VEGFR|{Ziv-aflibercept} Technical Information|{Ziv-aflibercept} References|{Ziv-aflibercept} manufacturer|{Ziv-aflibercept} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.Target: mTORSMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington’s disease and familial Parkinson’s disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington’s disease cell and Drosophila melanogaster models, which suggests therapeutic potential.|Product information|CAS Number: 944153-47-3|Molecular Weight: 287.PMID:32472497 74|Formula: C16H14ClNO2|Chemical Name: (2Z)-1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]but-2-en-1-one|Smiles: C/C(=C/C(=O)C1C=CC(Cl)=CC=1)/NC1C=C(O)C=CC=1|InChiKey: SNEQASFEVWLKOJ-LUAWRHEFSA-N|InChi: InChI=1S/C16H14ClNO2/c1-11(18-14-3-2-4-15(19)10-14)9-16(20)12-5-7-13(17)8-6-12/h2-10,18-19H,1H3/b11-9-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|