Product Name :
BMS-927711
Description:
Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile.
CAS:
1289023-67-1
Molecular Weight:
534.56
Formula:
C28H28F2N6O3
Chemical Name:
(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-9-yl 4-{2-oxo-1H,2H,3H-imidazo[4,5-b]pyridin-1-yl}piperidine-1-carboxylate
Smiles :
N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)N2C3=CC=CN=C3NC2=O)C2=NC=CC=C21)C1=CC=CC(F)=C1F
InChiKey:
KRNAOFGYEFKHPB-ANJVHQHFSA-N
InChi :
InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rimegepant, also known as BMS-927711 and BHV-3000, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraines. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile.|Product information|CAS Number: 1289023-67-1|Molecular Weight: 534.56|Formula: C28H28F2N6O3|Chemical Name: (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-5H,6H,7H,8H,9H-cyclohepta[b]pyridin-9-yl 4-{2-oxo-1H,2H,3H-imidazo[4,5-b]pyridin-1-yl}piperidine-1-carboxylate|Smiles: N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)N2C3=CC=CN=C3NC2=O)C2=NC=CC=C21)C1=CC=CC(F)=C1F|InChiKey: KRNAOFGYEFKHPB-ANJVHQHFSA-N|InChi: InChI=1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{ATPA} medchemexpress|{ATPA} iGluR|{ATPA} Activator|{ATPA} Protocol|{ATPA} In Vitro|{ATPA} custom synthesis} |Shelf Life: ≥360 days if stored properly.{{Prednisolone} site|{Prednisolone} Metabolic Enzyme/Protease|{Prednisolone} Biological Activity|{Prednisolone} In Vivo|{Prednisolone} custom synthesis|{Prednisolone} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23756629 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|