Product Name :
BLT-1
Description:
BLT-1 is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.
CAS:
321673-30-7
Molecular Weight:
241.40
Formula:
C12H23N3S
Chemical Name:
2-Hexyl-1-cyclopentanone thiosemicarbazone
Smiles :
CCCCCCC1CCC/C/1=N/NC(N)=S
InChiKey:
OWGUSBISUVLUJF-KAMYIIQDSA-N
InChi :
InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BLT-1 is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.{{Pyridostigmine} medchemexpress|{Pyridostigmine} Cholinesterase (ChE)|{Pyridostigmine} Biological Activity|{Pyridostigmine} Purity|{Pyridostigmine} supplier|{Pyridostigmine} Cancer} |Product information|CAS Number: 321673-30-7|Molecular Weight: 241.{{Golodirsen} MedChemExpress|{Golodirsen} Technical Information|{Golodirsen} In stock|{Golodirsen} supplier|{Golodirsen} Epigenetic Reader Domain} 40|Formula: C12H23N3S|Synonym:|Block lipid transport-1|Chemical Name: 2-Hexyl-1-cyclopentanone thiosemicarbazone|Smiles: CCCCCCC1CCC/C/1=N/NC(N)=S|InChiKey: OWGUSBISUVLUJF-KAMYIIQDSA-N|InChi: InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.PMID:23399686 67 mg/mL (172.62 mM; Need ultrasonic) H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells. BLT-1 has an IC50 of 0.96 μM for the HCV entry in Huh 7.5.1 cells. BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM).|References:|Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7.Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72.Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22.Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529.Products are for research use only. Not for human use.|