Anti-Mouse IL-1 beta SAFIRE Purified
The B122 monoclonal antibody specifically reacts with the precursor and mature secreted forms of mouse IL-1β and is cross-reactive with rat IL-1β. IL-1α and IL-1β are recognized by the same cell surface receptor but are generated from distinct genes. The B122 antibody is reported to neutralize the bioactivity of natural or recombinant IL-1β. Opicapone
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Clone
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B122
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Format: |
SAFIRE Purified
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Applications
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FA, Neutralization
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Reactivity
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Mouse, Rat
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Hogquist, K. A., Nett, M. A., Sheehan, K. C., Pendleton, K. D., Schreiber, R. D., & Chaplin, D. D. (1991). Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo. The Journal of immunology, 146(5), 1534-1540. Fei, R., Gott, K., Edwards, B., & Schuyler, M. (1995). Experimental hypersensitivity pneumonitis: in vitro effects of interleukin-2 and interferon-gamma. The Journal of laboratory and clinical medicine, 126(5), 485-494. Miller, B. E., Krasney, P. A., Gauvin, D. M., Holbrook, K. B., Koonz, D. J., Abruzzese, R. V., … & Ator, M. A. (1995). Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme. The Journal of Immunology,154(3), 1331-1338. |