Product Name :
264W94
Description:
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action.
CAS:
178961-24-5
Molecular Weight:
417.56
Formula:
C23H31NO4S
Chemical Name:
(3R,5R)-3-butyl-3-ethyl-7,8-dimethoxy-5-phenyl-2,3,4,5-tetrahydro-1λ⁶,4-benzothiazepine-1,1-dione
Smiles :
CCCC[C@@]1(CS(=O)(=O)C2=CC(OC)=C(C=C2[C@H](N1)C1C=CC=CC=1)OC)CC
InChiKey:
CKFWDLFFXXVSBJ-DHIUTWEWSA-N
InChi :
InChI=1S/C23H31NO4S/c1-5-7-13-23(6-2)16-29(25,26)21-15-20(28-4)19(27-3)14-18(21)22(24-23)17-11-9-8-10-12-17/h8-12,14-15,22,24H,5-7,13,16H2,1-4H3/t22-,23-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action.|Product information|CAS Number: 178961-24-5|Molecular Weight: 417.56|Formula: C23H31NO4S|Chemical Name: (3R,5R)-3-butyl-3-ethyl-7,8-dimethoxy-5-phenyl-2,3,4,5-tetrahydro-1λ⁶,4-benzothiazepine-1,1-dione|Smiles: CCCC[C@@]1(CS(=O)(=O)C2=CC(OC)=C(C=C2[C@H](N1)C1C=CC=CC=1)OC)CC|InChiKey: CKFWDLFFXXVSBJ-DHIUTWEWSA-N|InChi: InChI=1S/C23H31NO4S/c1-5-7-13-23(6-2)16-29(25,26)21-15-20(28-4)19(27-3)14-18(21)22(24-23)17-11-9-8-10-12-17/h8-12,14-15,22,24H,5-7,13,16H2,1-4H3/t22-,23-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Crosstide} medchemexpress|{Crosstide} Akt|{Crosstide} Protocol|{Crosstide} Purity|{Crosstide} supplier|{Crosstide} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Teniposide} web|{Teniposide} Cell Cycle/DNA Damage|{Teniposide} Purity & Documentation|{Teniposide} References|{Teniposide} supplier|{Teniposide} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24733396 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|264W94 (0, 0.1, 0.25, 0.5 μM) inhibits human IBAT-specific transport of 5 μM TC by 14% to 75% in a concentration-dependent manner with IC50 of 0.25 μM in CHO-hIBAT cells.|In Vivo:|264W94 (orally; 0.03-1.0 mg/kg; twice a day for 3.5 days) dose-dependently attenuates diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C. 264W94 (orally; 0.003, 0.01, 0.03, 0.1 mg/kg; twice a day for 2 days) increases fecal excretion of 75SeHCAT in a dose-dependent manner. 264W94 (0.001, 0.01, 0.1, 1, and 10 mg/kg; twice a day for 2 weeks) reduces dose-dependently plasma glucose in male ZDF (ZDF/GmiCrl-fa/fa) rats. Treatment of 264W94 prevents the decline of insulin dose-dependently without an increase in proinsulin levels.|Products are for research use only. Not for human use.|