Product Name :
IWP-3
Description:
IC50: 40 nM IWP-3 is an inhibitor of Wnt production. Wnt signaling proteins, a group of small secreted proteins, are active in tissue homeostasis, embryonic development, as well as tumorigenesis. Wnt proteins can bind to the cell surface receptors, initiating a signaling cascade that results in the β-catenin activation of gene transcription. In vitro: In previous study, IWP-3 was identified as an inhibitor of Wnt production that could regulate in vitro Wnt pathway activity with an IC50 value of 40 nM. In addition, IWP-3 was found to be able to inactivate porcupine, a O-acyltransferase for palmitoylating Wnt proteins that was critical for the signaling ability and secretion. Moreover, IWP-3 at 5 μM was found to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 and the scaffold protein Dishevelled, resulting in preventing the accumulation of β-catenin . In another study, IWP-3 was applied to promote cardiomyocyte generation from human embryonic stem cells by inhibiting Wnt signaling . In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, IWP-3 is still in the preclinical development stage.
CAS:
687561-60-0
Molecular Weight:
484.59
Formula:
C22H17FN4O2S3
Chemical Name:
2-{[3-(4-fluorophenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
Smiles :
CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC(F)=CC=3)=NC=2C=C1
InChiKey:
XVMHQSDMKWQNBK-UHFFFAOYSA-N
InChi :
InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 40 nM IWP-3 is an inhibitor of Wnt production. Wnt signaling proteins, a group of small secreted proteins, are active in tissue homeostasis, embryonic development, as well as tumorigenesis. Wnt proteins can bind to the cell surface receptors, initiating a signaling cascade that results in the β-catenin activation of gene transcription. In vitro: In previous study, IWP-3 was identified as an inhibitor of Wnt production that could regulate in vitro Wnt pathway activity with an IC50 value of 40 nM. In addition, IWP-3 was found to be able to inactivate porcupine, a O-acyltransferase for palmitoylating Wnt proteins that was critical for the signaling ability and secretion.{{Romidepsin} web|{Romidepsin} Apoptosis|{Romidepsin} Biological Activity|{Romidepsin} Formula|{Romidepsin} custom synthesis|{Romidepsin} Epigenetic Reader Domain} Moreover, IWP-3 at 5 μM was found to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 and the scaffold protein Dishevelled, resulting in preventing the accumulation of β-catenin .{{CPDA} MedChemExpress|{CPDA} Metabolic Enzyme/Protease|{CPDA} Biological Activity|{CPDA} In stock|{CPDA} manufacturer|{CPDA} Autophagy} In another study, IWP-3 was applied to promote cardiomyocyte generation from human embryonic stem cells by inhibiting Wnt signaling .PMID:23577779 In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, IWP-3 is still in the preclinical development stage.|Product information|CAS Number: 687561-60-0|Molecular Weight: 484.59|Formula: C22H17FN4O2S3|Chemical Name: 2-{[3-(4-fluorophenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide|Smiles: CC1=CC2SC(NC(=O)CSC3=NC4CCSC=4C(=O)N3C3C=CC(F)=CC=3)=NC=2C=C1|InChiKey: XVMHQSDMKWQNBK-UHFFFAOYSA-N|InChi: InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|