Anti-Human CD180 (RP-105) SAFIRE Purified
The MHR73-11 monoclonal antibody binds to human CD180, a 105kDA cell surface molecule consisting of extracellular leucine rich repeats (LCC) and a short cytoplasmic tail also known as Bgp-95 and RP105. CD180 is expressed on B cells, dendritic cells, monocytes, and macrophages. It forms a cell surface receptor complex with MD-1 and with TLR4 is involved with the recognition of bacterial lipopolysaccharide (LPS). The MHR73-11 antibody is reported to protect against dexamethasone and irradiation induced apoptosis in B cells. SBE-β-CD
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Clone
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MHR73-11
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Miura, Y., Shimazu, R., Miyake, K., Akashi, S., Ogata, H., Yamashita, Y., … & Kimoto, M. (1998). RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood, 92(8), 2815-2822. Miguet, L., Lennon, S., Baseggio, L., Traverse-Glehen, A., Berger, F., Perrusson, N., … & Mauvieux, L. (2013). Cell-surface expression of the TLR homolog CD180 in circulating cells from splenic and nodal marginal zone lymphomas. Leukemia, 27(8), 1748-1750. Koarada, S., Tada, Y., Sohma, Y., Haruta, Y., Suematsu, R., Mitamura, M., … & Nagasawa, K. (2010). Autoantibody-producing RP105− B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects. Rheumatology, 49(4), 662-670. |