Anti-Mouse IL-4 SAFIRE Purified
The 11B11 monoclonal antibody specifically reacts with mouse 14 kDa cytokine IL-4, expressed by the activated NKT cells and mast cells. IL-4 is species-specific and stimulates the proliferation and differentiation of B lymphocytes. It upregulates the expression of IgE receptors and class II MHC antigen.
The 11B11 antibody neutralizes the IL-4 cytokine.
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Clone
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11B11
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Format: |
SAFIRE Purified
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Applications
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FC, FA, IHC, IF, ELISA
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Reactivity
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Mouse
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Isotype:
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Rat IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Abrams, John S. Immunoenzymetric assay of mouse and human cytokines using NIP–labeled anti–cytokine antibodies. John Wiley & Sons, Inc., 1995. Ohara, J., and W. E. Paul. “Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1.” Nature 315.6017 (1985): 333. Haak-Frendscho, M., Brown, J. F., Iizawa, Y. U. J. I., Wagner, R. D., & Czuprynski, C. J. (1992). Administration of anti-IL-4 monoclonal antibody 11B11 increases the resistance of mice to Listeria monocytogenes infection. The Journal of Immunology, 148(12), 3978-3985. |