Anti-Human CD105 (Endoglin) PE
The SN6 monoclonal antibody specifically reacts with human CD105 (Endoglin), a 90kDA homodimeric glycoprotein expressed on vascular endothelial cells, activated macrophages, and a subset of bone marrow cells. CD105 is a marker for tumor angiogenesis research by identifying proliferating endothelium. It is also suggested to be involved in embryonic angiogenesis and cellular adhesion. GNE-617 (hydrochloride)
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Clone
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SN6
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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Mouse IgG1
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Pierelli, L., Bonanno, G., Rutella, S., Marone, M., Scambia, G., & Leone, G. (2001). CD105 (endoglin) expression on hematopoietic stem/progenitor cells.Leukemia & lymphoma, 42(6), 1195-1206. She, X., Matsuno, F., Harada, N., Tsai, H., & Seon, B. K. (2004). Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐β in suppression of growth of human endothelial cells. International journal of cancer, 108(2), 251-257. Seon, B. K., & Kumar, S. (2002). CD105 antibody for targeting of tumor vascular endothelial cells. In The new angiotherapy (pp. 499-515). Humana Press. |