Name : IL-31, Human
Product Concentration :
Background :
Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Biological Activity :
Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5.0 ng/ml of rHuIL-31 can effectively induce STAT3 activation.
expression system :
E. coli
Tag :
IL-31 (Ser24-Thr164)Accession # Q6EBC2
Protein Accession No. :
Q6EBC2
Synonyms :
IL31; IL-31; interleukin 31
Molecular Weight :
Purity :
> 97% as analyzed by SDS-PAGE> 97% as analyzed by HPLC
Product Concentration :
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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