Product Name :
NRX-252262
Description:
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
CAS:
2438637-61-5
Molecular Weight:
545.36
Formula:
C23H17Cl2F3N2O4S
Chemical Name:
4-[(2,6-dichlorophenyl)sulfanyl]-3-(5,6-dimethoxy-2,3-dihydro-1H-isoindole-2-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one
Smiles :
COC1C=C2CN(CC2=CC=1OC)C(=O)C1=C(C=C(NC1=O)C(F)(F)F)SC1C(Cl)=CC=CC=1Cl
InChiKey:
SPAYLOCXFWJEBL-UHFFFAOYSA-N
InChi :
InChI=1S/C23H17Cl2F3N2O4S/c1-33-15-6-11-9-30(10-12(11)7-16(15)34-2)22(32)19-17(8-18(23(26,27)28)29-21(19)31)35-20-13(24)4-3-5-14(20)25/h3-8H,9-10H2,1-2H3,(H,29,31)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.|Product information|CAS Number: 2438637-61-5|Molecular Weight: 545.36|Formula: C23H17Cl2F3N2O4S|Chemical Name: 4-[(2,6-dichlorophenyl)sulfanyl]-3-(5,6-dimethoxy-2,3-dihydro-1H-isoindole-2-carbonyl)-6-(trifluoromethyl)-1,2-dihydropyridin-2-one|Smiles: COC1C=C2CN(CC2=CC=1OC)C(=O)C1=C(C=C(NC1=O)C(F)(F)F)SC1C(Cl)=CC=CC=1Cl|InChiKey: SPAYLOCXFWJEBL-UHFFFAOYSA-N|InChi: InChI=1S/C23H17Cl2F3N2O4S/c1-33-15-6-11-9-30(10-12(11)7-16(15)34-2)22(32)19-17(8-18(23(26,27)28)29-21(19)31)35-20-13(24)4-3-5-14(20)25/h3-8H,9-10H2,1-2H3,(H,29,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 8.Ostarine Autophagy 33 mg/mL (15.LL-37 amide Epigenetics 27 mM; Need ultrasonic).PMID:32875950 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells.|References:|Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.Products are for research use only. Not for human use.|