Product Name :
Chrysosplenetin
Description:
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A.
CAS:
603-56-5
Molecular Weight:
374.34
Formula:
C19H18O8
Chemical Name:
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3, 6, 7-trimethoxy-4H-chromen-4-one
Smiles :
COC1C(=CC2OC(=C(OC)C(=O)C=2C=1O)C1=CC(OC)=C(O)C=C1)OC
InChiKey:
NBVTYGIYKCPHQN-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A.|Product information|CAS Number: 603-56-5|Molecular Weight: 374.34|Formula: C19H18O8|Chemical Name: 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3, 6, 7-trimethoxy-4H-chromen-4-one|Smiles: COC1C(=CC2OC(=C(OC)C(=O)C=2C=1O)C1=CC(OC)=C(O)C=C1)OC|InChiKey: NBVTYGIYKCPHQN-UHFFFAOYSA-N|InChi: InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Diroximel Technical Information |Shelf Life: ≥360 days if stored properly.Asundexian Metabolic Enzyme/Protease |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32046510 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380.Products are for research use only. Not for human use.|