Product Name :
Tau-441 (2N4R variant) (human), (recombinant)
Sequence:
Purity:
≥90% (SDS-PAGE)
Molecular Weight:
~45.9kDa
Solubility :
Appearance:
Use/Stability :
Description:
The tau proteins are major neuronal microtubule-associated proteins that function in the stabilization of microtubules and accumulate in various abnormal filaments including neurofibrillary tangles, neuropil threads and amyloid plaques in the pathology of Alzheimer’s disease.1454846-35-5 web Six tau isoforms are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.312961-83-4 supplier 8 to 45.9 kDa). The six isoforms differ from one another in having three or four microtubule binding repeats (R) and two, one or zero amino terminal inserts (N). While the fetal brain contains a single isoform of tau (TAU-352), the adult brain has several isoforms.PMID:20301357
CAS :
Solubility:
Formula:
Additional Information :
| Application Notes This protein is purified without any acid treatment and is suitable for promoting microtubule assembly, and for hyperphosphorylation-induced self-assembly into filaments. | Formulation Lyophilized from 50mM MES, pH 6.8, 100mM sodium chloride and 0.5mM EGTA. | MW ~45.9kDa | Purity ≥90% (SDS-PAGE) | Reconstitution Reconstitute with distilled water to a concentration of 1mg/ml. | Source Produced in E. coli. | UniProt ID P10636