Product Name :
PDE10A (catalytic domain) (human), (recombinant)
Sequence:
Purity:
Molecular Weight:
37 kDa
Solubility :
Appearance:
Use/Stability :
Description:
This enzyme can hydrolyze both cAMP and cGMP, but has a higher affinity for cAMP. In the brain it is present in neuronal cell bodies and neuropil of the striatum, in striatonigral and striatopallidal white matter tracks, and in the substantia nigra and globus pallidus.{{717907-75-0} web|{717907-75-0} Protocol|{717907-75-0} Purity|{717907-75-0} supplier} Outside the brain it is found in the testis, epididymal sperm, and enteric ganglia1.{{2417371-71-0} site|{2417371-71-0} Biological Activity|{2417371-71-0} References|{2417371-71-0} manufacturer} It is under investigation as a drug target for schizophrenia and diabetes.PMID:20301329
CAS :
Solubility:
Formula:
Additional Information :
| Alternative Name Phosphodiesterase 10A | Application Notes Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. | Formulation Liquid. In 20mM Tris-HCl, pH 7.5, containing 150mM NaCl, 2mM DTT. | MW 37 kDa | Source Produced in E. coli. Active catalytic domain of phosphodiesterase 10A. | UniProt ID Q9Y233