Product Name :
Inecalcitol
Description:
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities.
CAS:
163217-09-2
Molecular Weight:
400.59
Formula:
C26H40O3
Chemical Name:
(1R,3R)-5-{2-[(1R,3aR,4E,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}cyclohexane-1,3-diol
Smiles :
CC(C)(O)C#CC[C@@H](C)[C@H]1CC[C@@H]2/C(/CCC[C@]12C)=C/C=C1C[C@@H](O)C[C@H](O)C1
InChiKey:
HHGRMHMXKPQNGF-WNSNRMDMSA-N
InChi :
InChI=1S/C26H40O3/c1-18(7-5-13-25(2,3)29)23-11-12-24-20(8-6-14-26(23,24)4)10-9-19-15-21(27)17-22(28)16-19/h9-10,18,21-24,27-29H,6-8,11-12,14-17H2,1-4H3/b20-10+/t18-,21-,22-,23-,24-,26-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities.|Product information|CAS Number: 163217-09-2|Molecular Weight: 400.59|Formula: C26H40O3|Chemical Name: (1R,3R)-5-{2-[(1R,3aR,4E,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}cyclohexane-1,3-diol|Smiles: CC(C)(O)C#CC[C@@H](C)[C@H]1CC[C@@H]2/C(/CCC[C@]12C)=C/C=C1C[C@@H](O)C[C@H](O)C1|InChiKey: HHGRMHMXKPQNGF-WNSNRMDMSA-N|InChi: InChI=1S/C26H40O3/c1-18(7-5-13-25(2,3)29)23-11-12-24-20(8-6-14-26(23,24)4)10-9-19-15-21(27)17-22(28)16-19/h9-10,18,21-24,27-29H,6-8,11-12,14-17H2,1-4H3/b20-10+/t18-,21-,22-,23-,24-,26-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Baicalin} web|{Baicalin} Autophagy|{Baicalin} Protocol|{Baicalin} Description|{Baicalin} supplier|{Baicalin} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Rifalazil} web|{Rifalazil} Anti-infection|{Rifalazil} NF-κB|{Rifalazil} Protocol|{Rifalazil} In Vitro|{Rifalazil} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32119399 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Inecalcitol (0.1-10 nM; 48 hours) treatment of LNCaP cells results in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner. Inecalcitol (0.1-10 nM; 48 hours) also decreases ETV1 expression levels in a dose-dependent manner. Inecalcitol (10-14 days) inhibits the growth of LNCaP and HL-60 cells with ED50 values of 4.0 nM and 0.28 nM, respectively.|In Vivo:|Inecalcitol (1.3 mg/kg; i.p.; 3 times per week; for 42 days) inhibits androgen-responsive prostate cancer growth in vivo. Pharmacokinetic studies show that plasma half-life of Inecalcitol (C57Bl/6J mice; 1.3 mg/kg; i.p.) is 18.3 minutes in mice.|Products are for research use only. Not for human use.|