Product Name :
Zopolrestat
Description:
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications.
CAS:
110703-94-1
Molecular Weight:
419.38
Formula:
C19H12F3N3O3S
Chemical Name:
2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid
Smiles :
OC(=O)CC1=NN(CC2=NC3=CC(=CC=C3S2)C(F)(F)F)C(=O)C2=CC=CC=C12
InChiKey:
BCSVCWVQNOXFGL-UHFFFAOYSA-N
InChi :
InChI=1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications.|Product information|CAS Number: 110703-94-1|Molecular Weight: 419.38|Formula: C19H12F3N3O3S|Chemical Name: 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid|Smiles: OC(=O)CC1=NN(CC2=NC3=CC(=CC=C3S2)C(F)(F)F)C(=O)C2=CC=CC=C12|InChiKey: BCSVCWVQNOXFGL-UHFFFAOYSA-N|InChi: InChI=1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Pirtobrutinib} web|{Pirtobrutinib} Btk|{Pirtobrutinib} Biological Activity|{Pirtobrutinib} References|{Pirtobrutinib} supplier|{Pirtobrutinib} Cancer} |Shelf Life: ≥12 months if stored properly.{{Bliretrigine} medchemexpress|{Bliretrigine} Sodium Channel|{Bliretrigine} Technical Information|{Bliretrigine} References|{Bliretrigine} manufacturer|{Bliretrigine} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33086312 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Zopolrestat is a potent inhibitor of the reduction of both glyceraldehyde and glucose by the human and rat enzymes.|In Vivo:|Zopolrestat (2.5 mg/kg-50 mg/kg; p.o.; once-a-day for 5 days) and left untreated for 7 days) prevents accumulation of sorbitol in the kidney cortex of diabetic rats and normalize elevated renal blood flow in galactosemic rats.|Products are for research use only. Not for human use.|