Product Name :
Thalidomide-O-COOH
Description:
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.
CAS:
1061605-21-7
Molecular Weight:
332.26
Formula:
C15H12N2O7
Chemical Name:
2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetic acid
Smiles :
OC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
ZVWIXIGBWIEDFO-UHFFFAOYSA-N
InChi :
InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.|Product information|CAS Number: 1061605-21-7|Molecular Weight: 332.26|Formula: C15H12N2O7|Synonym:|Cereblon ligand 3|E3 ligase Ligand 3|TCE35031|Chemical Name: 2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetic acid|Smiles: OC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: ZVWIXIGBWIEDFO-UHFFFAOYSA-N|InChi: InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 66 mg/mL(198.{{Stenoparib} site|{Stenoparib} Cell Cycle/DNA Damage|{Stenoparib} NF-κB|{Stenoparib} Biological Activity|{Stenoparib} Data Sheet|{Stenoparib} manufacturer} 63 mM).{{Alectinib} site|{Alectinib} Anaplastic lymphoma kinase (ALK)|{Alectinib} Technical Information|{Alectinib} Purity|{Alectinib} custom synthesis|{Alectinib} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33257208 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Krajcovicova S, et al. Chem Commun (Camb). 2019 Jan 17;55(7):929-932.Products are for research use only. Not for human use.|