Product Name :
Cryptotanshinone
Description:
Cryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. It has been reported in the past that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression.
CAS:
35825-57-1
Molecular Weight:
296.36
Formula:
C19H20O3
Chemical Name:
(1R)-1,6,6-trimethyl-1H,2H,6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione
Smiles :
C[C@H]1COC2C3C=CC4=C(CCCC4(C)C)C=3C(=O)C(=O)C=21
InChiKey:
GVKKJJOMQCNPGB-JTQLQIEISA-N
InChi :
InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Hetrombopag} MedChemExpress|{Hetrombopag} Thrombopoietin Receptor|{Hetrombopag} Purity & Documentation|{Hetrombopag} Purity|{Hetrombopag} manufacturer|{Hetrombopag} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Cryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity.{{EPI-743} web|{EPI-743} Metabolic Enzyme/Protease|{EPI-743} Immunology/Inflammation|{EPI-743} Technical Information|{EPI-743} In Vivo|{EPI-743} supplier} It has been reported in the past that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression.PMID:27017949 |Product information|CAS Number: 35825-57-1|Molecular Weight: 296.36|Formula: C19H20O3|Chemical Name: (1R)-1,6,6-trimethyl-1H,2H,6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione|Smiles: C[C@H]1COC2C3C=CC4=C(CCCC4(C)C)C=3C(=O)C(=O)C=21|InChiKey: GVKKJJOMQCNPGB-JTQLQIEISA-N|InChi: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|