Product Name :
AZD-9291 mesylate
Description:
Osimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Osimertinib was approved in Nov. 2015 by FDA.
CAS:
1421373-66-1
Molecular Weight:
595.71
Formula:
C29H37N7O5S
Chemical Name:
(Z)-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enimidic acid; methanesulfonic acid
Smiles :
CN(C)CCN(C)C1=CC(OC)=C(C=C1/N=C(\O)/C=C)NC1=NC(=CC=N1)C1=CN(C)C2=CC=CC=C12.CS(O)(=O)=O
InChiKey:
FUKSNUHSJBTCFJ-UHFFFAOYSA-N
InChi :
InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Eicosapentaenoic Acid} site|{Eicosapentaenoic Acid} Histone Demethylase|{Eicosapentaenoic Acid} Protocol|{Eicosapentaenoic Acid} Data Sheet|{Eicosapentaenoic Acid} custom synthesis|{Eicosapentaenoic Acid} Epigenetics}
Shelf Life:
≥360 days if stored properly.{{GSK1059615} MedChemExpress|{GSK1059615} PI3K/Akt/mTOR|{GSK1059615} Immunology/Inflammation|{GSK1059615} Biological Activity|{GSK1059615} In stock|{GSK1059615} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25959043
Additional information:
Osimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Osimertinib was approved in Nov. 2015 by FDA.|Product information|CAS Number: 1421373-66-1|Molecular Weight: 595.71|Formula: C29H37N7O5S|Chemical Name: (Z)-N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enimidic acid; methanesulfonic acid|Smiles: CN(C)CCN(C)C1=CC(OC)=C(C=C1/N=C(\O)/C=C)NC1=NC(=CC=N1)C1=CN(C)C2=CC=CC=C12.CS(O)(=O)=O|InChiKey: FUKSNUHSJBTCFJ-UHFFFAOYSA-N|InChi: InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|