Product Name :
Afegostat D-Tartrate
Description:
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.
CAS:
957230-65-8
Molecular Weight:
297.26
Formula:
C10H19NO9
Chemical Name:
(2S,3S)-2,3-dihydroxybutanedioic acid; (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol
Smiles :
OC[C@H]1CNC[C@@H](O)[C@@H]1O.{{(-)-(S)-Equol} medchemexpress|{(-)-(S)-Equol} Metabolic Enzyme/Protease|{(-)-(S)-Equol} Technical Information|{(-)-(S)-Equol} Purity|{(-)-(S)-Equol} supplier|{(-)-(S)-Equol} Autophagy} OC(=O)[C@@H](O)[C@H](O)C(O)=O
InChiKey:
ULBPPCHRAVUQMC-AWUBODBRSA-N
InChi :
InChI=1S/C6H13NO3.C4H6O6/c8-3-4-1-7-2-5(9)6(4)10;5-1(3(7)8)2(6)4(9)10/h4-10H,1-3H2;1-2,5-6H,(H,7,8)(H,9,10)/t4-,5-,6-;1-,2-/m10/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity.|Product information|CAS Number: 957230-65-8|Molecular Weight: 297.{{VV116} site|{VV116} RSV|{VV116} Protocol|{VV116} References|{VV116} manufacturer|{VV116} Autophagy} 26|Formula: C10H19NO9|Chemical Name: (2S,3S)-2,3-dihydroxybutanedioic acid; (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol|Smiles: OC[C@H]1CNC[C@@H](O)[C@@H]1O.OC(=O)[C@@H](O)[C@H](O)C(O)=O|InChiKey: ULBPPCHRAVUQMC-AWUBODBRSA-N|InChi: InChI=1S/C6H13NO3.PMID:24282960 C4H6O6/c8-3-4-1-7-2-5(9)6(4)10;5-1(3(7)8)2(6)4(9)10/h4-10H,1-3H2;1-2,5-6H,(H,7,8)(H,9,10)/t4-,5-,6-;1-,2-/m10/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.|Products are for research use only. Not for human use.|