Product Name :
BIBF0775
Description:
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). X-ray structure analysis showed that BIBF0775 soaked into the kinase domain of TGFβRI.
CAS:
334951-90-5
Molecular Weight:
494.63
Formula:
C31H34N4O2
Chemical Name:
(3Z)-N-Ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide
Smiles :
CN(CC)C(=O)C1=CC2NC(=O)/C(=C(\NC3C=CC(CN4CCCCC4)=CC=3)/C3C=CC=CC=3)/C=2C=C1
InChiKey:
MUSRTIADFPCYTQ-ZIADKAODSA-N
InChi :
InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fosinopril} MedChemExpress|{Fosinopril} Apoptosis|{Fosinopril} Protocol|{Fosinopril} In stock|{Fosinopril} manufacturer|{Fosinopril} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Repotrectinib} medchemexpress|{Repotrectinib} Trk Receptor|{Repotrectinib} Protocol|{Repotrectinib} In stock|{Repotrectinib} custom synthesis|{Repotrectinib} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:27108903
Additional information:
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). X-ray structure analysis showed that BIBF0775 soaked into the kinase domain of TGFβRI.|Product information|CAS Number: 334951-90-5|Molecular Weight: 494.63|Formula: C31H34N4O2|Synonym:|BIBF-0775|BIBF 0775|Chemical Name: (3Z)-N-Ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide|Smiles: CN(CC)C(=O)C1=CC2NC(=O)/C(=C(\NC3C=CC(CN4CCCCC4)=CC=3)/C3C=CC=CC=3)/C=2C=C1|InChiKey: MUSRTIADFPCYTQ-ZIADKAODSA-N|InChi: InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P,Mennerich D, Schnapp A, Park JE. Design, synthesis, and evaluation of indolinonesas inhibitors of the transforming growth factor β receptor I (TGFβRI). J MedChem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a. PubMed PMID: 20919678.Products are for research use only. Not for human use.|