Product Name :
STK16-IN-1
Description:
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
CAS:
1223001-53-3
Molecular Weight:
293.30
Formula:
C17H12FN3O
Chemical Name:
1-(4-fluoro-3-methylphenyl)-1H,2H,7H-pyrrolo[2,3-h]1,6-naphthyridin-2-one
Smiles :
CC1=CC(=CC=C1F)N1C(=O)C=CC2=CN=C3NC=CC3=C12
InChiKey:
WQNRDXHKVSKUPI-UHFFFAOYSA-N
InChi :
InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Dalfopristin} site|{Dalfopristin} Antibiotic|{Dalfopristin} Technical Information|{Dalfopristin} In stock|{Dalfopristin} manufacturer|{Dalfopristin} Autophagy}
Additional information:
STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.|Product information|CAS Number: 1223001-53-3|Molecular Weight: 293.30|Formula: C17H12FN3O|Chemical Name: 1-(4-fluoro-3-methylphenyl)-1H,2H,7H-pyrrolo[2,3-h]1,6-naphthyridin-2-one|Smiles: CC1=CC(=CC=C1F)N1C(=O)C=CC2=CN=C3NC=CC3=C12|InChiKey: WQNRDXHKVSKUPI-UHFFFAOYSA-N|InChi: InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 15 mg/mL (51.{{Cabotegravir} MedChemExpress|{Cabotegravir} Membrane Transporter/Ion Channel|{Cabotegravir} Biological Activity|{Cabotegravir} Purity|{Cabotegravir} supplier|{Cabotegravir} Cancer} 14 mM; Need ultrasonic and warming).PMID:24624203 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 inhibits mTOR kinase with an IC50 of 5.56 μM. In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16).|Products are for research use only. Not for human use.|