Product Name :
Chk1-IN-5
Description:
Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model.
CAS:
2120398-39-0
Molecular Weight:
387.41
Formula:
C18H22FN7O2
Chemical Name:
5-({5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]pyrazolidin-3-yl}amino)pyrazine-2-carbonitrile
Smiles :
COC1=CC(F)=CC(OCCCN)=C1C1CC(NN1)NC1=CN=C(C=N1)C#N
InChiKey:
OECWXHGRBWTUAM-UHFFFAOYSA-N
InChi :
InChI=1S/C18H22FN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-6,9-10,13,16,25-26H,2-4,7,20H2,1H3,(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{EML4-ALK kinase inhibitor 1} medchemexpress|{EML4-ALK kinase inhibitor 1} Anaplastic lymphoma kinase (ALK)|{EML4-ALK kinase inhibitor 1} Purity & Documentation|{EML4-ALK kinase inhibitor 1} In Vivo|{EML4-ALK kinase inhibitor 1} manufacturer|{EML4-ALK kinase inhibitor 1} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model.|Product information|CAS Number: 2120398-39-0|Molecular Weight: 387.41|Formula: C18H22FN7O2|Chemical Name: 5-({5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]pyrazolidin-3-yl}amino)pyrazine-2-carbonitrile|Smiles: COC1=CC(F)=CC(OCCCN)=C1C1CC(NN1)NC1=CN=C(C=N1)C#N|InChiKey: OECWXHGRBWTUAM-UHFFFAOYSA-N|InChi: InChI=1S/C18H22FN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-6,9-10,13,16,25-26H,2-4,7,20H2,1H3,(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Zonisamide} site|{Zonisamide} Apoptosis|{Zonisamide} Purity & Documentation|{Zonisamide} Data Sheet|{Zonisamide} supplier|{Zonisamide} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:35850484 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Chk1-IN-5 (compound 3; 0.4, 1.2, 3.7, 11.1, 33.3, 100 nM) inhibits Chk1 phosphorylation in the HT-29 colon cells.|In Vivo:|Chk1-IN-5 (compound 3; 40 mg/kg; IV; twice a week for 21 days) inhibits tumor growth in Baib/c nude mice with HT-29 colon cancer cells. Chk1-IN-5 (10 mg/kg; via tail vein intravenous injection) displays a longer half-life (T1/2=3.8 hours) and higher exposure (CL=2.3 L/hr•kg; Vss=6.4 L/kg; AUC=4531 ng/ml•h).|Products are for research use only. Not for human use.|